Polymyocyte sodium salt
polyinosinic-polycytidylic acid sodium
CAS: 42424-50-0
Molecular Formula: C19H27N7O16P2
Polymyocyte sodium salt - Names and Identifiers
Polymyocyte sodium salt - Physico-chemical Properties
| Molecular Formula | C19H27N7O16P2 |
| Molar Mass | 671.41 |
| Solubility | H2O: soluble10mg/mL |
| Appearance | lyophilized powder |
| Storage Condition | −20°C |
| In vivo study | Polyinosinic-polycytidylic acid treatment inhibits tumor growth in NOD/SCID immunodeficient mice injected with 1205Lu cells. The level of human DNA is 50% lower in mice treated with Polyinosinic-polycytidylic acid. |
Polymyocyte sodium salt - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | TR0175000 |
Polymyocyte sodium salt - Reference
| Reference Show more | 1. [IF=9.229] Ting He et al."Hyalase-Mediated Cascade Degradation of a Matrix Barrier and Immune Cell Penetration by a Photothermal Microneedle for Efficient Anticancer Therapy."Acs Appl Mater Inter. 2021;13(23):26790–26799 |
Polymyocyte sodium salt - Reference Information
| Biological activity | Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA, an agonist of TLR3 and retinoic acid inducible gene I receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses and alter the microenvironment of tumors, and can also directly trigger apoptosis in cancer cells. |
| target | TLR3, RIG-I, MDA5, apoptosis |
| Cell Line: | WM793, WM278, WM239A, WM9 and 1205Lu cells 1205Lu cells 1205Lu cells 1205Lu cells |
| Concentration: | 20 ng/mL 200 ng/mL 3 ng/mL 5 ng/mL |
| Incubation Time: | 24 hours 24 hours 24 hours 24 hours |
| Result: | Strongly reduced viability from 100% in controls to 20%–50% within 24 hours. Induced apoptosis in 1205Lu cells. Induced IFN-β expression in melanoma cells. Revealed active subunits of caspase-9 and caspase-8 in melanoma cells. |
| Use | A double-stranded homopolymer that can be used as a model RNA for studying cell signal transduction at the TLR3 level. It is also a TRIF-dependent toll-like receptor -3(TLR3) ligand. |
Last Update：2024-04-09 02:00:08
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View History
Polymyocyte sodium salt
OXBILE POWDER
Acide elaidique
(4-Fluorophenyl)acetic acid
TRIMETHYL-N-OCTYLAMMONIUM CHLORIDE
PD-1PD-L1 inhibitor
2-METHYLNEROL
OXBILE POWDER
Acide elaidique
(4-Fluorophenyl)acetic acid
TRIMETHYL-N-OCTYLAMMONIUM CHLORIDE
PD-1PD-L1 inhibitor
2-METHYLNEROL